CATH Domain 1m99A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
	1.20.1050.10

Domain Context

CATH Clusters

Superfamily	1.20.1050.10
Functional Family	Glutathione S-transferase 2

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt P08515

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P08515

GST26_SCHJA

Schistosoma japonicum

Glutathione S-transferase class-mu 26 kDa isozyme

PDB Structure

PDB	1M99
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum Cardoso, R.M.F., Daniels, D.S., Bruns, C.M., Tainer, J.A. PROTEINS: STRUCT.,FUNCT.,GENET.