CATH Domain 1i2zA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9

Enoyl-[acyl-carrier-protein] reductase (NADH).

based on mapping to UniProt P0AEK4

An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.

-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P0AEK4

FABI_ECOLI

Escherichia coli K-12

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

PDB Structure

PDB	1I2Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Heerding, D.A., Chan, G., DeWolf, W.E., Fosberry, A.P., Janson, C.A., Jaworski, D.D., McManus, E., Miller, W.H., Moore, T.D., Payne, D.J., Qiu, X., Rittenhouse, S.F., Slater-Radosti, C., Smith, W., Takata, D.T., Vaidya, K.S., Yuan, C.C., Huffman, W.F. Bioorg.Med.Chem.Lett.