CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.220 | Chondroitinase Ac; Chain A, domain 3 |
|
2.60.220.10 | Polysaccharide lyase family 8-like, C-terminal |
Domain Context
CATH Clusters
| Superfamily | Polysaccharide lyase family 8-like, C-terminal |
| Functional Family |
Enzyme Information
| 4.2.2.5 |
Chondroitin AC lyase.
based on mapping to UniProt Q59288
Eliminative degradation of polysaccharides containing 1,4-beta-D- hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
-!- Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. -!- In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. -!- The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1- 3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. -!- GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of DS. -!- Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source. -!- Formerly EC 4.2.99.6.
|
UniProtKB Entries (1)
| Q59288 |
CSLA_PEDHD
Pedobacter heparinus DSM 2366
Chondroitinase-AC
|
PDB Structure
| PDB | 1HM3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Pedobacter |
| Primary Citation |
Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
Biochemistry
|
