CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt P05979
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

P05979
PGH1_SHEEP
Ovis aries
Prostaglandin G/H synthase 1

PDB Structure

PDB 1FE2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases.
Thuresson, E.D., Malkowski, M.G., Lakkides, K.M., Rieke, C.J., Mulichak, A.M., Ginell, S.L., Garavito, R.M., Smith, W.L.
J.Biol.Chem.
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