CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.410 | Cholesterol Oxidase; domain 2 |
|
3.30.410.10 | Cholesterol Oxidase; domain 2 |
Domain Context
CATH Clusters
| Superfamily | Cholesterol Oxidase; domain 2 |
| Functional Family |
Enzyme Information
| 1.1.3.6 |
Cholesterol oxidase.
based on mapping to UniProt P22637
Cholesterol + O(2) = cholest-5-en-3-one + H(2)O(2).
-!- Cholesterol oxidases are secreted bacterial bifunctional enzymes that catalyze the first two steps in the degradation of cholesterol. -!- The enzyme catalyzes the oxidation of the 3-beta-hydroxyl group to a keto group, and the isomerization of the double bond in the oxidized steroid ring system from the Delta(5) position to the Delta(6) position (cf. EC 5.3.3.1).
|
| 5.3.3.1 |
Steroid Delta-isomerase.
based on mapping to UniProt P22637
A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.
|
UniProtKB Entries (1)
| P22637 |
CHOD_BREST
Brevibacterium sterolicum
Cholesterol oxidase
|
PDB Structure
| PDB | 1COY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases.
Biochemistry
|
