CATH Domain 1ay6H01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P01050	HIRV1_HIRME Hirudo medicinalis Hirudin variant-1

PDB	1AY6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif Greco, M.N., Powell, E.T., Hecker, L.R., Andrade-Gordon, P., Kauffman, J.A., Lewis, J.M., Ganesh, V., Tulinsky, A., Maryanoff, B.E. Bioorg.Med.Chem.Lett.