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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 623780: ABC transporter, ATP-binding protein

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sulfate-transporting ATPase. [EC: 3.6.3.25]
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
  • A bacterial enzyme that imports sulfate and thiosulfate anions.
 141 A0A021XDH0 A0A031IAS0 A0A031JEX9 A0A060UPB1 A0A063BAX5 A0A064BPJ3 A0A073CP75 A0A075KJ97 A0A077S8V0 A0A080NH00
(131 more...)
Polyamine-transporting ATPase. [EC: 3.6.3.31]
ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In).
  • A bacterial enzyme that imports putrescine and spermidine.
 58 A0A024C7H4 A0A060PVS1 B5Z778 B6JLU8 C7BZE3 E1PZH4 E1S8L9 E8QPK2 H8H4H7 I9Q715
(48 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 29 A0A084ZSA4 A0A085G1W0 A0A085GPF5 A0A085H3H2 A0A085HDW6 A0A085HFI3 A0A085ILV9 A0A085JQC3 A0A095BVD8 A0A097R6B1
(19 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 25 A0A084ZSA4 A0A085G1W0 A0A085GPF5 A0A085H3H2 A0A085HDW6 A0A085HFI3 A0A085ILV9 A0A085JQC3 A0A097R6B1 A0A0B9AIC4
(15 more...)
Fe(3+)-transporting ATPase. [EC: 3.6.3.30]
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
  • A bacterial enzyme that imports ferric cations.
 14 C5ARD5 D5VBX6 E6XB90 F0RFC7 F2IJG3 F4GJP0 F4KNK5 F4KYM4 F6DE40 G8NS32
(4 more...)
DNA-directed RNA polymerase. [EC: 2.7.7.6]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
  • See also EC 2.7.7.19 and EC 2.7.7.48.
 7 A0A061Q6H9 A0A0A3ER59 A0A0C1YWU3 A0A0C1ZGC4 A6AT54 A8T966 K5UMZ3
Nonpolar-amino-acid-transporting ATPase. [EC: 3.6.3.22]
ATP + H(2)O + nonpolar amino acid(Out) = ADP + phosphate + nonpolar amino acid(In).
  • Comprises bacterial enzymes that import Leu, Ile and Val.
 5 A0A1C9VKK6 A0A1L1PAB5 C9YEX3 I9C0R3 Q0KEN3
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. [EC: 2.3.1.129]
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
  • Involved with EC 2.4.1.182 and EC 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
 5 A0A0F3QPJ6 C4K0F8 H8LPW5 Q7PC07 Q92HW2
Phosphate-transporting ATPase. [EC: 3.6.3.27]
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
  • A bacterial enzyme that imports phosphate anions.
 5 A0A061CVJ6 A0A0Q4TKN7 A0A1H2NA39 U1UCR0 W6R6Q1
Lipopolysaccharide-transporting ATPase. [EC: 3.6.3.39]
ATP + H(2)O + lipopolysaccharide(In) = ADP + phosphate + lipopolysaccharide(Out).
  • Enzymes of Gram-negative bacteria that export lipo-oligosaccharides and lipopolysaccharides.
 1 V5V4A2
Molybdate-transporting ATPase. [EC: 3.6.3.29]
ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In).
  • A bacterial enzyme that imports molybdate anions.
 1 G3IRK1
Cytosol nonspecific dipeptidase. [EC: 3.4.13.18]
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
  • Broad specificity, varying somewhat with source species.
  • Activated and stabilized by dithiothreitol and manganese.
  • Inhibited by bestatin and leucine.
  • Belongs to peptidase family M20.
  • Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.3, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.3, EC 3.4.13.8, EC 3.4.13.11, EC 3.4.13.13 and EC 3.4.13.15.
 1 U2XVF8
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