# STOCKHOLM 1.0
#=GF ID 3.40.430.10/FF/2037
#=GF DE Dfr1p
#=GF AC 3.40.430.10/FF/2037
#=GF TP FunFam
#=GF DR CATH: 4.2
#=GF DR DOPS: 39.789
#=GS P07807/4-211      AC P07807
#=GS P07807/4-211      OS Saccharomyces cerevisiae S288C
#=GS P07807/4-211      DE Dihydrofolate reductase
#=GS P07807/4-211      DR GENE3D; 5595cec2fd54ffbd03175513911eeea5/4-211; 
#=GS P07807/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS P07807/4-211      DR GO; GO:0003729; GO:0004146; GO:0005829; GO:0046452; GO:0046654; 
#=GS P07807/4-211      DR EC; 1.5.1.3; 
#=GS B3LJQ7/4-211      AC B3LJQ7
#=GS B3LJQ7/4-211      OS Saccharomyces cerevisiae RM11-1a
#=GS B3LJQ7/4-211      DE Dihydrofolate reductase
#=GS B3LJQ7/4-211      DR GENE3D; 5595cec2fd54ffbd03175513911eeea5/4-211; 
#=GS B3LJQ7/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS B3LJQ7/4-211      DR EC; 1.5.1.3; 
#=GS N1P3I2/4-211      AC N1P3I2
#=GS N1P3I2/4-211      OS Saccharomyces cerevisiae CEN.PK113-7D
#=GS N1P3I2/4-211      DE Dfr1p
#=GS N1P3I2/4-211      DR GENE3D; 5595cec2fd54ffbd03175513911eeea5/4-211; 
#=GS N1P3I2/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS N1P3I2/4-211      DR EC; 1.5.1.3; 
#=GS C8ZGZ0/4-211      AC C8ZGZ0
#=GS C8ZGZ0/4-211      OS Saccharomyces cerevisiae EC1118
#=GS C8ZGZ0/4-211      DE Dfr1p
#=GS C8ZGZ0/4-211      DR GENE3D; 5595cec2fd54ffbd03175513911eeea5/4-211; 
#=GS C8ZGZ0/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS C8ZGZ0/4-211      DR EC; 1.5.1.3; 
#=GS H0GNU8/1-193      AC H0GNU8
#=GS H0GNU8/1-193      OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7
#=GS H0GNU8/1-193      DE Dfr1p
#=GS H0GNU8/1-193      DR GENE3D; 2388b4f4aca3ddac31dccd425d230f2e/1-193; 
#=GS H0GNU8/1-193      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae x Saccharomyces kudriavzevii; 
#=GS H0H1D7/1-193      AC H0H1D7
#=GS H0H1D7/1-193      OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7
#=GS H0H1D7/1-193      DE Dfr1p
#=GS H0H1D7/1-193      DR GENE3D; 4810d061f2dc7d9183c62e48a4cbba46/1-193; 
#=GS H0H1D7/1-193      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae x Saccharomyces kudriavzevii; 
#=GS J4TW37/4-211      AC J4TW37
#=GS J4TW37/4-211      OS Saccharomyces kudriavzevii IFO 1802
#=GS J4TW37/4-211      DE DFR1-like protein
#=GS J4TW37/4-211      DR GENE3D; 53ababef78209dc6f6cb0df6f2c014d3/4-211; 
#=GS J4TW37/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces kudriavzevii; 
#=GS L0P7T1/4-214      AC L0P7T1
#=GS L0P7T1/4-214      OS Pneumocystis jirovecii SE8
#=GS L0P7T1/4-214      DE Uncharacterized protein
#=GS L0P7T1/4-214      DR GENE3D; 58fce98dab8761d237c024645f5671b2/4-214; 
#=GS L0P7T1/4-214      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Pneumocystidomycetes; Pneumocystidales; Pneumocystidaceae; Pneumocystis; Pneumocystis jirovecii; 
#=GS J8Q1T3/4-211      AC J8Q1T3
#=GS J8Q1T3/4-211      OS Saccharomyces arboricola H-6
#=GS J8Q1T3/4-211      DE Dfr1p
#=GS J8Q1T3/4-211      DR GENE3D; 69829fd8ff685bd4b1fad2119cf68072/4-211; 
#=GS J8Q1T3/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces arboricola; 
#=GS E7NML8/1-177      AC E7NML8
#=GS E7NML8/1-177      OS Saccharomyces cerevisiae FostersO
#=GS E7NML8/1-177      DE Dfr1p
#=GS E7NML8/1-177      DR GENE3D; b586a059fe6d689aeafd3315ee20c201/1-177; 
#=GS E7NML8/1-177      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E7M0L1/1-177      AC E7M0L1
#=GS E7M0L1/1-177      OS Saccharomyces cerevisiae Vin13
#=GS E7M0L1/1-177      DE Dfr1p
#=GS E7M0L1/1-177      DR GENE3D; b586a059fe6d689aeafd3315ee20c201/1-177; 
#=GS E7M0L1/1-177      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E7KUJ2/1-177      AC E7KUJ2
#=GS E7KUJ2/1-177      OS Saccharomyces cerevisiae Lalvin QA23
#=GS E7KUJ2/1-177      DE Dfr1p
#=GS E7KUJ2/1-177      DR GENE3D; b586a059fe6d689aeafd3315ee20c201/1-177; 
#=GS E7KUJ2/1-177      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS A0A0L8VH25/4-211  AC A0A0L8VH25
#=GS A0A0L8VH25/4-211  OS Saccharomyces sp. 'boulardii'
#=GS A0A0L8VH25/4-211  DE DFR1p Dihydrofolate reductase involved in tetrahydrofolate biosynthesis
#=GS A0A0L8VH25/4-211  DR GENE3D; dce5a8b4442d4da8e854dd87883f4f9d/4-211; 
#=GS A0A0L8VH25/4-211  DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces sp. 'boulardii'; 
#=GS A6ZP76/4-211      AC A6ZP76
#=GS A6ZP76/4-211      OS Saccharomyces cerevisiae YJM789
#=GS A6ZP76/4-211      DE Dihydrofolate reductase
#=GS A6ZP76/4-211      DR GENE3D; dce5a8b4442d4da8e854dd87883f4f9d/4-211; 
#=GS A6ZP76/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS G2WNA5/4-211      AC G2WNA5
#=GS G2WNA5/4-211      OS Saccharomyces cerevisiae Kyokai no. 7
#=GS G2WNA5/4-211      DE K7_Dfr1p
#=GS G2WNA5/4-211      DR GENE3D; e71e1ddfbbff9179ec7e2804d30f828f/4-211; 
#=GS G2WNA5/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS C7GWF0/4-211      AC C7GWF0
#=GS C7GWF0/4-211      OS Saccharomyces cerevisiae JAY291
#=GS C7GWF0/4-211      DE Dfr1p
#=GS C7GWF0/4-211      DR GENE3D; e71e1ddfbbff9179ec7e2804d30f828f/4-211; 
#=GS C7GWF0/4-211      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E7KIA1/1-156      AC E7KIA1
#=GS E7KIA1/1-156      OS Saccharomyces cerevisiae AWRI796
#=GS E7KIA1/1-156      DE Dfr1p
#=GS E7KIA1/1-156      DR GENE3D; a1041dce2ef5ab32617cee51b803ab1f/1-156; 
#=GS E7KIA1/1-156      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E7Q9C5/1-156      AC E7Q9C5
#=GS E7Q9C5/1-156      OS Saccharomyces cerevisiae FostersB
#=GS E7Q9C5/1-156      DE Dfr1p
#=GS E7Q9C5/1-156      DR GENE3D; 5e34643a729e7709649cbdef56e7694b/1-156; 
#=GS E7Q9C5/1-156      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GF TC 360.8 1.1E-111
#=GF SQ 18
P07807/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
B3LJQ7/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
N1P3I2/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
C8ZGZ0/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
H0GNU8/1-193              ---------------MGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
H0H1D7/1-193              ---------------MGIGFQGGLPWRLSKEMKFFRQVTSSTKDANKKNAVVMGRKTWESIPSKFRPLPNRMNVVISRSFKDGFVHDEEESIIKSNSLVNALTNLQNKFQESLEKIYVIGGGEVYNQIFPITDHWLITKIHSLDNEAAPAMDTFLDAKRLKETFSEQDPAQLKEFLPPKVDLPETDSDQRYSQEEKGYH--FEFTLYNR-R
J4TW37/4-211              GKIPIVGIVACLQPDMGIGFQGGLPWRLSKEMKFFRQVTSSTKDANKKNAVVMGRKTWESIPPKFRPLPNRMNVVISRSFKDGFVHDEEESIIKSNSLANALTNLQNKFQESLEKIYVIGGGEVYNQIFPITDHWLITKIHSLDNEAAPAMDTFLDAKRLKEAFSEQDPAQLKEFLPPKVDLPETDSDQRYSQEEKGYH--FEFTLYNR-R
L0P7T1/4-214              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKKHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYSAGFEFTLYNLIE
J8Q1T3/4-211              GKIPVVGIVACLQPDMGIGFQGGLPWRLPKEMKYFRQVTSSTKDSNKKNAVIMGRKTWESIPPKFRPLPNRMNVVISRSFDDGFDHDKEKSIIRSNSLANALTNLQNKFQDSLERIYVIGGGEVYNQIFPITDHWLITKICTLDKTTVPAMDTFLDAKRLKEAFSEQDPAQLKEFLPPIVELPETKFDQRYIQEEKGYH--LEFTLFNR-R
E7NML8/1-177              -------------------------------MKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
E7M0L1/1-177              -------------------------------MKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
E7KUJ2/1-177              -------------------------------MKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
A0A0L8VH25/4-211          GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKGDFVHDKERSIVQSNSLANAITNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
A6ZP76/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKGDFVHDKERSIVQSNSLANAITNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
G2WNA5/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAITNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
C7GWF0/4-211              GKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAITNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
E7KIA1/1-156              ----------------------------------------------------MGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
E7Q9C5/1-156              ----------------------------------------------------MGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAITNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYC--FEFTLYNR-K
#=GC scorecons            2222122222222213333323333333223555555555355545555545999999999989999999999979999988797997969977999989975997779776998999999999979997999999999966997686999999999979796999999999999999798999986999986999996008999989807
#=GC scorecons_70         ____________________________________________________**************************************************_************************************************************************************************__********_*
#=GC scorecons_80         ____________________________________________________******************************_******_***_********_***__***_*************_***_**********__***_*_************_*_***********************_*****_*****___********_*
#=GC scorecons_90         ____________________________________________________**********************_*******_*_**_*_**__*******__**___*___**_**********_***_**********__**__*_**********_*_*_***************_*_*****_****__*****___********__
//