CATH Domain 6nn9A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt P03472

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P03472

NRAM_I75A5

Influenza A virus (A/tern/Australia/G70C/1975(H11N9))

Neuraminidase

PDB Structure

PDB	6NN9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. Tulip, W.R., Varghese, J.N., Baker, A.T., van Donkelaar, A., Laver, W.G., Webster, R.G., Colman, P.M. J.Mol.Biol.