CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.1120 | Arylsulfatase, C-terminal domain | |
3.30.1120.30 | POLO box domain |
Domain Context
CATH Clusters
Superfamily | POLO box domain |
Functional Family | Serine/threonine-protein kinase PLK |
Enzyme Information
2.7.11.21 |
Polo kinase.
based on mapping to UniProt Q07832
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (2)
Q07832 |
PLK1_MOUSE
Mus musculus
Serine/threonine-protein kinase PLK1
|
Q14511 |
CASL_HUMAN
Homo sapiens
Enhancer of filamentation 1
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PDB Structure
PDB | 5X3S |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.
J. Biol. Chem.
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