CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.429 | Macrophage Migration Inhibitory Factor |
|
3.30.429.10 | Macrophage Migration Inhibitory Factor |
Domain Context
CATH Clusters
| Superfamily | Macrophage Migration Inhibitory Factor |
| Functional Family |
Enzyme Information
| 5.3.2.6 |
2-hydroxymuconate tautomerase.
based on mapping to UniProt Q01468
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate.
-!- Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. -!- The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex- 3-enedioate by the enzyme. -!- Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme but later shown to be produced non-enzymatically.
|
UniProtKB Entries (1)
| Q01468 |
4OT1_PSEPU
Pseudomonas putida
2-hydroxymuconate tautomerase
|
PDB Structure
| PDB | 5CLO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.
Nat Commun
|
