CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.290 | Spermadhesin, CUB domain |
Domain Context
CATH Clusters
| Superfamily | Spermadhesin, CUB domain |
| Functional Family | mannan-binding lectin serine protease 1 isoform X1 |
Enzyme Information
| 3.4.21.104 |
Mannan-binding lectin-associated serine protease-2.
based on mapping to UniProt Q9JJS8
Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
-!- Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement. -!- Displays C1s-like esterolytic activity (cf. EC 3.4.21.42). -!- It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42. -!- Belongs to peptidase family S1A.
|
UniProtKB Entries (1)
| Q9JJS8 |
MASP2_RAT
Rattus norvegicus
Mannan-binding lectin serine protease 2
|
PDB Structure
| PDB | 5CIS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Structure
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