CATH Domain 3o95A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.140	8 Propeller
	2.140.10	Methanol Dehydrogenase; Chain A
	2.140.10.30	Dipeptidylpeptidase IV, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Dipeptidylpeptidase IV, N-terminal domain
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487

DPP4_HUMAN

Homo sapiens

Dipeptidyl peptidase 4

PDB Structure

PDB	3O95
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor. Miyamoto, Y., Banno, Y., Yamashita, T., Fujimoto, T., Oi, S., Moritoh, Y., Asakawa, T., Kataoka, O., Yashiro, H., Takeuchi, K., Suzuki, N., Ikedo, K., Kosaka, T., Tsubotani, S., Tani, A., Sasaki, M., Funami, M., Amano, M., Yamamoto, Y., Aertgeerts, K., Yano, J., Maezaki, H. J.Med.Chem.