CATH Domain 3n7oA02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Serine protease 37

3.4.21.39

Chymase.

based on mapping to UniProt P23946

Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.

-!- In mast cell granules. -!- Belongs to peptidase family S1.

CMA1_HUMAN

Homo sapiens

Chymase

PDB	3N7O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potency variation of small-molecule chymase inhibitors across species. Kervinen, J., Crysler, C., Bayoumy, S., Abad, M.C., Spurlino, J., Deckman, I., Greco, M.N., Maryanoff, B.E., de Garavilla, L. Biochem. Pharmacol.