CATH Domain 3b1tA01

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1860	Protein-arginine deiminase, N-terminal domain

Superfamily	Protein-arginine deiminase, N-terminal domain
Functional Family	Protein-arginine deiminase type-4

3.5.3.15

Protein-arginine deiminase.

based on mapping to UniProt Q9UM07

Protein L-arginine + H(2)O = protein L-citrulline + NH(3).

-!- Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.

PADI4_HUMAN

Homo sapiens

Protein-arginine deiminase type-4

PDB	3B1T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors Causey, C.P., Jones, J.E., Slack, J.L., Kamei, D., Jones Jr, L.E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A.A., Luo, Y., Hashimoto, H., Sato, M., Hofseth, L.J., Thompson, P.R. J.Med.Chem.