CATH Domain 1ks6A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.60	CD59
	2.10.60.10	CD59

Domain Context

CATH Clusters

Superfamily	CD59
Functional Family	TGF-beta receptor type-2

Enzyme Information

2.7.11.30

Receptor protein serine/threonine kinase.

based on mapping to UniProt Q90999

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q90999

TGFR2_CHICK

Gallus gallus

TGF-beta receptor type-2

PDB Structure

PDB	1KS6
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Solution structure of the chick TGFb type II receptor ligand binding domain Marlow, M.S., Brown, C.B., Barnett, J.V., Krezel, A.M. J.Mol.Biol.