CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.4.16.4
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt P15555
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

P15555
DAC_STRSR
Streptomyces sp. R61
D-alanyl-D-alanine carboxypeptidase

PDB Structure

PDB 1IKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
McDonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A.
J.Mol.Biol.
CATH-Gene3D is a Global Biodata Core Resource Learn more...