3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
Bell, I.M., Gallicchio, S.N., Abrams, M., Beese, L.S., Beshore, D.C., Bhimnathwala, H., Bogusky, M.J., Buser, C.A., Culberson, J.C., Davide, J., Ellis-Hutchings, M., Fernandes, C., Gibbs, J.B., Graham, S.L., Hamilton, K.A., Hartman, G.D., Heimbrook, D.C., Homnick, C.F., Huber, H.E., Huff, J.R., Kassahun, K., Koblan, K.S., Kohl, N.E., Lobell, R.B., Lynch Jr., J.J., Robinson, R., Rodrigues, A.D., Taylor, J.S., Walsh, E.S., Williams, T.M., Zartman, C.B.
J.Med.Chem.
